Evaluation of SNPs and miRNAs in the BID, MAPK10, and AGER Genes Related to Alzheimer's Disease by Using In Silico Tools

Alzheimer's disease (AD) is a multifactorial resulting from both genetic and environmental factors, which are pathologically defined by the accumulation of intracellular hyperphosphorylated tau protein, neurofibrils tangles, extracellular amyloid β protein in brain. The purpose this study to estimate potentially damaging effects missense single nucleotide polymorphisms (SNPs) BID, MAPK10 AGER genes associated with AD using various silico tools determine SNPs on miRNAs. In addition, it aimed gene-gene protein-protein interactions through software tools. Consequently, was estimated that there may be harmful seven BID gene, twenty-seven gene three gene. It obtained some decrease effectiveness miRNA-mRNA binding, enhance, break, create new binding zone and/or destroy genes. miRNA-SNP analyses could not provide information study, MAPK10, genes, high-risk SNPs, will able data for future genotyping studies. have role miRNA- mRNA activity can assessed as priority experimental studies related AD. future, proposed investigate clinical harmful/disease-related affecting mRNA-miRNA interaction.